Multisystem Inflammatory Syndrome in Children (MIS-C)

Date issued: 01/12/23

Effective January 1, 2023 a new surveillance case definition for multsystem inflammatory syndrome in children (MIS-C) was implemented for reproting cases of MIS-C.

MIS-C is a rare but severe complication in children and young adults infected with SARS-CoV-2 the virus that causes COVID-19.

The new case definition criteria can be viewed at Information for Healthcare Providers about Multisystem Inflammatory Syndrome in Children (MIS-C) CDC.

Key Changes to the Definition:

  • 1. No required duration of subjective or measured fever.

  • 2. A requirement of C-reactive protein greater than 3.0mg/dl to indicate systematic inflammation.

  • 3. Adjustments to criteria of organ system involvement to include addition of shock as a separate category and elimination of respiratory, neurologic and renal criteria.

  • 4. A new requirement on timing of a positive SARS-CoV-2 laboratory testing within 60 days of MIS-C illness.


  • Healthcare providers must report suspected cases of MIS-C by faxing the 2023 case report form to 717-772-6975 or to your local health department or by securely emailing the form to This email address is being protected from spambots. You need JavaScript enabled to view it..

  • Click HERE for the CASE REPORT FORM.  There is addtional case report guidance that can be referenced when completing the form.